RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Smad7
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
Northern Blot; qRT-PCR; Dual-luciferase reporter assay etc.
Target
Smad7
Pathway
NA
PubMed ID
Title
MiR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis
Year
2010
Function
"MiR-21 is up-regulated in the lungs of mice with bleomycin-induced fibrosis and also in the lungs of patients with IPF, and was primarily localized to myofibroblasts. Administration of miR-21 antisense probes diminished the severity of experimental lung fibrosis in mice, even when treatment was started 5-7 d after initiation of pulmonary injury. TGF-Beta1 enhanced miR-21 expression in primary pulmonary fibroblasts. Increasing miR-21 levels promoted, whereas knocking down miR-21 attenuated, the pro-fibrogenic activity of TGF-Beta1 in fibroblasts. A potential mechanism for the role of miR-21 in fibrosis is through regulating the expression of an inhibitory Smad, Smad7."